August 3, 2012Journal of Cellular and Molecular MedicineOpen Access

Cardiomyocyte Ca 2+ handling and structure is regulated by degree and duration of mechanical load variation

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Rat hearts

Intervention

Moderate mechanical unloading (using heterotopic abdominal heart-lung transplantation) for 4 or 8 weeks, and pressure overloading using thoracic aortic constriction for 6 or 10 weeks

Comparator

Severe mechanical unloading (using heart-only transplantation)

Outcome

Ca(2+)-induced Ca(2+) release (CICR), cell volume, and t-tubule structuresurrogate

Variations in chronic mechanical load influence local Ca2+-induced Ca2+ release and t-tubule structure in a time- and degree-dependent manner in rat hearts.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Moderate unloading attenuates rat cardiomyocyte atrophy less than severe unloading; leaves open optimal mechanical support levels in human heart failure.

Cite This Study

Ibrahim et al. (2012) studied this question.

synapsesocial.com/papers/6a90e42268768914f683003d https://doi.org/10.1111/j.1582-4934.2012.01611.x

Topics

Heart transplantation Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Implication

Moderate unloading attenuates rat cardiomyocyte atrophy less than severe unloading; leaves open optimal mechanical support levels in human heart failure.

Cardiomyocyte Ca 2+ handling and structure is regulated by degree and duration of mechanical load variation

Structured PICO

Discussion

Implication

Cite This Study

Topics

Cardiomyocyte Ca 2+ handling and structure is regulated by degree and duration of mechanical load variation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider