Why the study?
Does mechanical unloading alter Ca2+ cycling mechanisms to preserve systolic Ca2+ transients in syngeneic male Lewis rats?
Population
Syngeneic male Lewis rats (n=34), weight 270±5 g
Comparison
Mechanical unloading via heterotopic abdominal… vs Orthotopic hearts in the same recipient animal
Design
Preclinical, Randomly assigned either the orthotopic or the transplanted heart…
Follow-up
2 weeks
Authors
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May preserve Ca2+ transients via L-type influx in unloaded rat hearts; hypothesis-generating for human mechanical unloading or atrophy.
Does mechanical unloading alter Ca2+ cycling mechanisms to preserve systolic Ca2+ transients in syngeneic male Lewis rats?
In early cardiac atrophy induced by mechanical unloading, augmented sarcolemmal Ca2+ influx through L-type Ca2+ channels compensates for reduced systolic SR Ca2+ release to preserve the Ca2+ transient.
Schwoerer et al. (2013) studied this question.
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