Key result
Mechanical unloading of the failing heart reversed pathological t-tubule remodelling and improved Ca2+-induced Ca2+ release in a rodent model of heart failure.
Why the study?
Does mechanical unloading reverse t-tubule remodeling and improve Ca2+-induced Ca2+ release in a rodent model of heart failure?
Population
Lewis rats with heart failure induced by left coronary artery ligation for 12 weeks
Comparison
Mechanical unloading for 4 weeks by heterotopic… vs Sham-operated animals and failing hearts without…
Design
Preclinical
Follow-up
4 weeks
Authors
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Mechanical unloading may restore t-tubule integrity in failing hearts; leaves open translation to human LVAD outcomes.
Does mechanical unloading reverse t-tubule remodeling and improve Ca2+-induced Ca2+ release in a rodent model of heart failure?
Mechanical unloading of the failing heart in a rodent model reverses pathological t-tubule remodeling and improves calcium-induced calcium release, providing a mechanistic basis for reverse remodeling seen with LVADs.
Ibrahim et al. (2012) studied Heart failure. Mechanical unloading (heterotopic abdominal heart transplantation) vs. Sham-operated controls and non-unloaded failing hearts was evaluated on t-tubule structure and Ca2+-induced Ca2+ release (CICR). Mechanical unloading of the failing heart reversed pathological t-tubule remodelling and improved Ca2+-induced Ca2+ release in a rodent model of heart failure.
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