Why the study?
Because obesity and cardiac disease frequently coincide, understanding how adipose tissues and the heart coordinate and interact is important for identifying potential therapeutic strategies for diabetes and cardiovascular disease.
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Design
Review
Highlights the importance of adipose-heart crosstalk and its potential as a therapeutic target in patients with diabetes and cardiovascular disease.
It is important to understand how different human organs coordinate and interact with each other. Since obesity and cardiac disease frequently coincide, the crosstalk between adipose tissues and heart has drawn attention. We appreciate that specific peptides/proteins, lipids, nucleic acids, and even organelles shuttle between the adipose tissues and heart. These bioactive components can profoundly affect the metabolism of cells in distal organs, including heart. Importantly, this process can be dysregulated under pathophysiological conditions. This also opens the door to efforts targeting these mediators as potential therapeutic strategies to treat patients who manifest diabetes and cardiovascular disease. Here, we summarize the recent progress toward a better understanding of how the adipose tissues and heart interact with each other.
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Li et al. (2022) studied this question.
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