Transcatheter Aortic Valve Replacement for Degenerative Bioprosthetic Surgical Valves
Why the study?
Does transcatheter aortic valve-in-valve implantation provide effective and safe outcomes in patients with degenerated bioprosthetic valves?
Population
202 patients with degenerated bioprosthetic valves from 38 cardiac centers worldwide. Bioprosthesis mode of…
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Supports valve-in-valve feasibility in high-risk patients; leaves open randomized comparisons to surgical reintervention.
Structured PICO
Does transcatheter aortic valve-in-valve implantation provide effective and safe outcomes in patients with degenerated bioprosthetic valves?
P
Population
202 patients with degenerated bioprosthetic valves (aged 77.7±10.4 years; 52.5% men) from 38 cardiac centers worldwide. Bioprosthesis mode of failure was stenosis (42%), regurgitation (34%), or combined (24%).
I
Intervention
Transcatheter aortic valve-in-valve implantation using CoreValve (n=124) or Edwards SAPIEN (n=78)
O
Outcome
Procedural success, adverse procedural outcomes, post-procedure hemodynamics, 30-day mortality, and 1-year survivalhard clinical
Transcatheter valve-in-valve implantation is a clinically effective alternative for patients with degenerated bioprosthetic surgical valves, though device malposition and coronary obstruction remain safety concerns.
Cite This Study
Dvir et al. (2012) studied this question.