Why the study?
To introduce a 01-1D cardiovascular model and parameter assignment methodology to reproduce age- and sex-related physiological changes in arterial pressure and cardiac hemodynamics.
A 01-1D cardiovascular model successfully generated a virtual population capable of reproducing age- and sex-related physiological changes in arterial pressure and cardiac hemodynamics.
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Should not yet change practice; extends 1D modeling but leaves open prospective validation.
This study introduces a 01-1D cardiovascular model and a parameter assignment methodology to reproduce age- and sex-related physiological changes in arterial pressure and cardiac hemodynamics. Uniform sampling of input parameters was conducted to generate a virtual population, encompassing the variability of healthy individuals. A systematic analysis was performed to identify parameter combinations that led to exclusion of implausible virtual subjects. The virtual population was compared with a clinical dataset, demonstrating its potential for realistic physiological simulations.
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Wardhana et al. (2025) studied this question.
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