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December 14, 2007Thrombosis and HaemostasisOpen Access

Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment

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Why the study?

Does multiple electrode platelet aggregometry (MEA) correlate with light transmission aggregometry (LTA) in assessing ADP-induced platelet aggregation before and after clopidogrel treatment in patients scheduled for coronary angiography?

Population

149 patients scheduled for coronary angiography

Comparison

Clopidogrel 600 mg vs Pre-treatment baseline (available in 60 patients)

Design

Cohort

Authors

SBSiegmund BraunInterventional / Structural CardiologySJStefan JawanskyTechnical University of MunichWVWolfgang VogtLinköping University

Discussion

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Implication

MEA offers a faster testing option; extends correlative evidence but leaves open outcome impact in clopidogrel-treated patients.

Key Points

  • To assess whether multiple electrode platelet aggregometry (MEA) in whole blood provides a rapid, standardized alternative to light transmission aggregometry (LTA) for evaluating platelet response to clopidogrel.
  • Evaluated 149 patients scheduled for coronary angiography after treatment with 600 mg of clopidogrel, including baseline pre-treatment samples in 60 patients.
  • Concurrently measured ADP-induced platelet aggregation in whole blood using MEA on the Multiplate analyzer and in platelet-rich plasma using standard LTA.
  • Platelet aggregation measured by MEA decreased significantly following clopidogrel administration (P < 0.0001).
  • ADP-induced platelet aggregation determined by MEA correlated significantly with traditional LTA measurements (Spearman rank correlation coefficient = 0.71; P < 0.0001).

Structured PICO

Does multiple electrode platelet aggregometry (MEA) correlate with light transmission aggregometry (LTA) in assessing ADP-induced platelet aggregation before and after clopidogrel treatment in patients scheduled for coronary angiography?

P
Population
149 patients scheduled for coronary angiography
I
Intervention
Clopidogrel 600 mg
C
Comparator
Pre-treatment baseline (available in 60 patients)
O
Outcome
ADP-induced platelet aggregation measured with multiple electrode platelet aggregometry (MEA) and light transmission aggregometry (LTA)surrogate

Multiple electrode platelet aggregometry (MEA) is a fast and standardized method that correlates well with traditional light transmission aggregometry (LTA) for assessing platelet response to clopidogrel.

Cite This Study

Braun et al. (2007) studied this question.

synapsesocial.com/papers/69fa89c79fa336b96d47d7d2https://doi.org/10.1160/th07-07-0478

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of the Concentration of Ca2+ in the Suspending Medium on the Responses of Human and Rabbit Platelets to Aggregating Agents1989 · 126 citations
  2. 2Variability in Individual Responsiveness to Clopidogrel2007 · 962 citations