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May 6, 2026Journal of onco-anaesthesiology and perioperative medicine.Open Access

Dexmedetomidine–Ketamine versus Ketamine–Propofol for Procedural Sedation in Cervical Cancer Patients Undergoing Intracavitary Brachytherapy: A Randomised Study

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Authors

STSakshi ThakoreAKAnkita KaasatNTNirdesh Thakore

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Overview

Randomised study found comparable sedation times and postoperative outcomes in cervical cancer patients undergoing intr"acavitary brachytherapy, indicating dexmedetomidine may be effective for day-sed

Key Points

  • The study aims to compare dexmedetomidine-ketamine and ketamine-propofol for procedural sedation in cervical cancer patients during intracavitary brachytherapy.
  • Conducted as a double-blind, parallel-arm trial
  • Involved 80 adult cervical cancer patients
  • Compared dexmedetomidine-ketamine versus ketamine-propofol for sedation
  • No significant differences in onset of sedation and recovery time were found
  • Dexmedetomidine- ketamine resulted in transient increases in blood pressure
  • Both groups showed stable cardiorespiratory parameters during the procedure

Cite This Study

Thakore et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e0b04f884e66b530683https://doi.org/10.4103/joapm.joapm_18_26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Evaluation of Dexmedetomidine-Ketamine versus Ketamine-Propofol for Procedural Sedation during Dilatation and Curettage: A Prospective Randomized Double-Blind Study2025
  2. 2Intravenous Dexmedetomidine-Ketamine Versus Ketamine-Propofol for Procedural Sedation in Adults Undergoing Short Surgical Procedures: A Randomized Controlled Trial2023 · 3 citations
  3. 3Comparative Evaluation of Effects of Propofol and Ketamine versus Dexmedetomidine and Ketamine on Blood Pressure, Heart Rate and Recovery of Patients undergoing Dilatation and Curettage2024
  4. 4Preemptive analgosedation with ketamine-dexmedetomidine versus ketamine-propofol in upper limb surgeries under supraclavicular brachial plexus block2022 · 3 citations
  5. 5Comparative Study between Intravenous Ketamine- Propofol Versus Ketamine- Dexmedetomidine for Sedation of Adult patients during Upper Gastrointestinal Endoscopy2025