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May 29, 2026Open Access

Comparative Study between Intravenous Ketamine- Propofol Versus Ketamine- Dexmedetomidine for Sedation of Adult patients during Upper Gastrointestinal Endoscopy

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Authors

AAAbdullah AL-SheikhAl-Azhar UniversityAAAli Al-KumityAl-Azhar UniversityISIbrahim SaadAl-Azhar University

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Overview

Randomized trial evaluates sedation effectiveness in adults undergoing upper gastrointestinal endoscopy, suggesting safety and efficacy of both combinations.

Key Points

  • To evaluate the safety profile, hemodynamics, and sedation quality of ketamine-propofol versus ketamine-dexmedetomidine during endoscopy in adults.
  • Randomized clinical trial with 60 adult patients undergoing upper gastrointestinal endoscopy, divided into two groups: ketamine-propofol and ketamine-dexmedetomidine.
  • Both groups received sedation and were monitored for heart rate, oxygen saturation, recovery time, and Ramsay sedation scores.
  • No significant differences in recovery time, mean arterial pressures, respiration rate, pain score, or Ramsay sedation levels between the two groups.
  • Significant differences in oxygen saturation levels were observed after the loading dose and endoscope insertion.
  • Group with ketamine-propofol had a shorter time to first rescue bolus compared to the ketamine-dexmedetomidine group.

Cite This Study

AL-Sheikh et al. (2025) studied this question.

synapsesocial.com/papers/6a192dd1fab5b468c4416bebhttps://doi.org/10.21608/aimj.2025.446460
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intravenous Dexmedetomidine-Ketamine Versus Ketamine-Propofol for Procedural Sedation in Adults Undergoing Short Surgical Procedures: A Randomized Controlled Trial2023 · 3 citations
  2. 2An analytical study of Comparison between Ketamine - Dexmedetomidine versus Ketamine - Propofol for Sedation in Children Undergoing Minor Cardiac Procedures in a Cardiac Catheterization Laboratory2021 · 1 citations
  3. 3Efficacy and Safety of Ketamine-Dexmedetomidine Versus Ketamine-Propofol Combination for Periprocedural Sedation: A Systematic Review and Meta-analysis2024 · 33 citations
  4. 4A Comparison of Dexmedetomidine with Ketamine (DEXKET) and Propofol with Ketamine (KETOFOL) During Endoscopic Retrograde Cholangi2025
  5. 5Safety and efficacy of dexmedetomidine vs ketamine vs midazolam combined with propofol in gastrointestinal endoscopy for cancer patients: A randomized double-blinded trial2023 · 1 citations