Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 6, 2026Critical CareOpen Access

Association between neurofilament light chain concentrations and outcomes in patients with moderate to severe traumatic brain injury: a systematic review and meta-analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

MBMarwan BourasCentre Hospitalier Régional Universitaire de BrestMPMathieu PageauUniversité LavalMGMarc-Aurèle GagnonUniversité Laval

Discussion

Loading...

Member takes

Implication

Systematic review associates higher neurofilament light chain levels with worse outcomes in traumatic brain injury, indicating a need for reliable biomarkers.

Key Points

  • Assess the relationship between neurofilament light chain concentrations and outcomes in moderate to severe TBI.
  • Conducted a systematic review and meta-analysis on the association of NfL levels with outcomes in TBI patients.
  • Included cohort studies and randomized controlled trials focusing on NfL levels in the acute phase.
  • Utilized Glasgow Outcome Scale scores to define long-term neurological function and mortality outcomes.
  • Higher NfL concentrations were linked to unfavorable neurological outcomes, with statistically significant associations.
  • Increased NfL levels correlated with higher mortality rates, especially when measured within 24 hours post-injury.
  • Evidential certainty was deemed very low due to risk of bias and variability in study results.

Cite This Study

Bouras et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e6404f884e66b530a33https://doi.org/10.1186/s13054-026-06036-3
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute-Phase Neurofilament Light and Glial Fibrillary Acidic Proteins in Cerebrospinal Fluid Predict Long-Term Outcome After Severe Traumatic Brain Injury2024 · 10 citations
  2. 2Parallel Cerebrospinal Fluid and Serum Temporal Profile Assessment of Axonal Injury Biomarkers Neurofilament-Light Chain and Phosphorylated Neurofilament-Heavy Chain: Associations With Patient Outcome in Moderate-Severe Traumatic Brain Injury2024 · 25 citations
  3. 3Serum Neurofilament Light Protein as a Marker for Diffuse Axonal Injury: Results from a Case Series Study2016 · 118 citations
  4. 4Serum neurofilament light chain at time of diagnosis is an independent prognostic factor of survival in amyotrophic lateral sclerosis2019 · 94 citations
  5. 5Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)2007 · 2,799 citations