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May 6, 2026Circulation

Abstract WE543: Association of Weekend Warrior and Other Physical Activity Patterns with Mortality Among Adults with Cardiovascular Diseases: A Cohort Study

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Key result

Weekend warrior activity pattern linked to ~28% lower all-cause mortality vs inactivity.

  • HR 0.72
  • 95% CI 0.64 to 0.80
  • n=82,031

Why the study?

Do weekend warrior and regularly active physical activity patterns reduce mortality in adults with cardiovascular diseases?

Population

82,031 U.S. adults with self-reported cardiovascular diseases from the National Health Interview Survey

Comparison

Weekend warrior or regularly active physical… vs Physically inactive

Design

Cohort

Follow-up

median 10.75 years

Authors

HLH W LiCapital Medical UniversityZWZhiyuan WuGoethe University Frankfurt

Discussion

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Implication

In adults with cardiovascular disease, meeting physical activity guidelines through either a 'weekend warrior' pattern or regular activity is associated with significantly lower all-cause and cardiovascular mortality compared to being inactive.

Key Points

  • To examine the associations of physical activity patterns with mortality among adults with cardiovascular diseases.
  • Prospective cohort study
  • Participants from National Health Interview Survey linked to National Death Index records
  • Categorized participants by physical activity groups: inactive, insufficiently active, weekend warriors, and regularly active
  • Recorded mortality over median follow-up of 10.75 years.
  • 29,273 deaths documented during the follow-up period
  • Weekend warriors had 28% lower risk of all-cause mortality compared to inactive
  • Regularly active participants had 33% lower risk of cardiovascular mortality compared to inactive
  • Few differences noted in cancer mortality among activity groups.

Study Design

Type

Cohort (n=82,031)

Structured PICO

Do weekend warrior and regularly active physical activity patterns reduce mortality in adults with cardiovascular diseases?

P
Population
82,031 U.S. adults with self-reported cardiovascular diseases, followed for a median of 10.75 years.
E
Exposure
Weekend warrior (moderate-to-vigorous physical activity [MVPA] ≥150 minutes per week in 1 to 2 sessions) or regularly active (MVPA ≥150 minutes per week in ≥3 sessions) physical activity patterns
C
Comparator
Physically inactive (reporting no moderate-to-vigorous physical activity [MVPA])
O
Outcome
All-cause mortalityhard clinical

Main Result

Hazard Ratio: 0.72 (95% CI 0.64–0.8)

In adults with cardiovascular disease, meeting physical activity guidelines through either a 'weekend warrior' pattern or regular activity is associated with significantly lower all-cause and cardiovascular mortality compared to being inactive.

Limitations

  • Physical activity was self-reported and assessed at a single time point.
  • Physical activity was self-reported
  • Physical activity was assessed at a single time point

Cite This Study

Li et al. (2026) conducted a cohort in cardiovascular diseases (n=82,031). Weekend warrior and regularly active physical activity patterns vs. Physically inactive (no moderate-to-vigorous physical activity) was evaluated on all-cause mortality (HR 0.72, 95% CI 0.64 to 0.80). Weekend warrior and regularly active physical activity patterns were associated with lower all-cause mortality (HR 0.72, 95% CI 0.64-0.80 and HR 0.83, respectively) compared with inactivity.

synapsesocial.com/papers/69fa8e8904f884e66b530c6ahttps://doi.org/10.1161/cir.153.suppl_1.we543
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Accelerometer-derived weekend warrior physical activity pattern and all-cause and cause-specific mortality in patients with cardiovascular disease2026 · 2 citations
  2. 2Weekend Warrior and other physical activity patterns: mortality and life expectancy in individuals with cardiometabolic multimorbidity2026
  3. 3Associations of “Weekend Warrior” Physical Activity With Incident Disease and Cardiometabolic Health2024 · 78 citations
  4. 4Association of accelerometer-measured physical activity patterns with cardiovascular diseases and mortality in people with osteoarthritis2026
  5. 5Accelerometer‐Derived “Weekend Warrior” Physical Activity Pattern and Venous Thromboembolism Incidence and Mortality: A Prospective Cohort Study2026