Key result
Weekend warrior activity linked to ~36% lower mortality vs inactivity in cardiometabolic multimorbidity.
Why the study?
This study examined the associations of different physical activity patterns with mortality risk and life expectancy among individuals with cardiometabolic multimorbidity.
Does meeting physical activity guidelines (either as a Weekend Warrior or Regularly Active) reduce mortality and improve life expectancy in adults with cardiometabolic multimorbidity compared to being inactive?
Cohort (n=15,079)
Does meeting physical activity guidelines (either as a Weekend Warrior or Regularly Active) reduce mortality and improve life expectancy in adults with cardiometabolic multimorbidity compared to being inactive?
Hazard Ratio: 0.64 (95% CI 0.49–0.83)
In adults with cardiometabolic multimorbidity, accumulating recommended physical activity in 1-2 sessions per week (Weekend Warrior) provides similar mortality reductions and life expectancy gains as more frequent regular activity.
Supports flexible activity patterns in multimorbidity; leaves open causal confirmation by randomized trials.
: Objectives This study examined the associations of different physical activity patterns with mortality risk and life expectancy among individuals with cardiometabolic multimorbidity. Design We analyzed data from adults with CMM in the National Health Interview Survey (1997–2018), linked to mortality records through December 31, 2019. CMM was defined as the coexistence of at least two of heart disease, diabetes, and stroke. Methods Physical activity was categorized as Inactive, Insufficiently Active, Weekend Warrior (≥150 min/week in 1–2 sessions), or Regularly Active (≥150 min/week in ≥3 sessions). Relative mortality risks were estimated using Cox proportional hazards models, absolute mortality rate differences using Poisson regression, and differences in life expectancy at ages 45 and 65 using flexible parametric survival models. Subgroup and sensitivity analyses assessed robustness. Results The analytic sample included 15,079 adults with CMM, of whom 8,299 (55.0%) were women. Over a mean follow-up of 10.1 years, 6,932 deaths occurred. Compared with Inactive participants, mortality risk was 19% lower among the Insufficiently Active (HR = 0.81, 95% CI: 0.75–0.89), 36% lower among Weekend Warriors (HR = 0.64, 95% CI: 0.49–0.83), and 40% lower among the Regularly Active (HR = 0.60, 95% CI: 0.55–0.65). At age 45, estimated differences in life expectancy were 2.24, 4.60, and 4.94 years across these groups, respectively; corresponding differences at age 65 were 1.46, 3.04, and 3.27 years. Conclusions Among individuals with CMM, recommended levels of physical activity, whether accumulated in 1-2 weekly sessions or more frequent exercise, were associated with lower mortality risk and longer life expectancy. Weekend Warrior and regular activity patterns showed comparable associations with survival-related outcomes.
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Huang et al. (2026) conducted a cohort in Cardiometabolic multimorbidity (n=15,079). Weekend Warrior physical activity pattern (≥150 min/week in 1-2 sessions) vs. Inactive (0 min/week) was evaluated on All-cause mortality (HR 0.64, 95% CI 0.49-0.83). The Weekend Warrior physical activity pattern was associated with a 36% lower risk of all-cause mortality (HR 0.64) compared to physical inactivity among adults with cardiometabolic multimorbidity.
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