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This research explores the pH regulation of the lysosomal arginine sensor SLC38A9.

May 6, 2026FEBS LettersOpen Access

pH ‐mediated activation of the lysosomal arginine sensor SLC38A9

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Investigating pH effects on amino acid transport in lysosomes reveals insights into mTORC1 signaling.

This research explores the pH regulation of the lysosomal arginine sensor SLC38A9.
Investigated how pH influences SLC38A9 activity and arginine uptake.
Examined the role of His544 as a pH sensor in SLC38A9.
Compared the structures of SLC38A9 at different pH levels to understand its activation.
Arginine uptake is demonstrated to be pH-dependent.
Mutation of His544 removes the pH dependence without affecting overall transport.
Demonstrated a model for pH-induced activation of SLC38A9 influencing mTORC1 signaling.

Mu et al. (2026) studied this question.

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