Synthesis of 2-(2-Methoxyphenyl)-4-methyl-6-nitroquinoline and 2-(2-Methoxyphenyl)-4-methylquinolin-6-amine

Rumen Lyapchev; M. S. Ivanova; Iskra Z. Koleva; Dimitar Shandurkov

doi:10.3390/m2168

April 30, 2026MolbankOpen Access

Synthesis of 2-(2-Methoxyphenyl)-4-methyl-6-nitroquinoline and 2-(2-Methoxyphenyl)-4-methylquinolin-6-amine

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Key Points

To synthesize and characterize two novel quinoline derivatives and assess their optical properties.
Performed a Suzuki reaction to obtain 2-(2-methoxyphenyl)-4-methyl-6-nitroquinoline.
Isolated an unexpected side product: 2-(2-methoxyphenyl)-4-methylquinolin-6-amine.
Confirmed the structures using 1H, 13C, and 2D-NMR spectroscopy.
Investigation of optical properties was conducted.
Successfully synthesized 2-(2-methoxyphenyl)-4-methyl-6-nitroquinoline compound.
Identified an unexpected byproduct: 2-(2-methoxyphenyl)-4-methylquinolin-6-amine.
Characterization confirmed novel structures and allowed for analysis of their optical properties.

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Implication

Synthesis reveals novel optical properties of compounds in quinoline derivatives, suggesting potential applications.

Abstract

A new compound, 2-(2-methoxyphenyl)-4-methyl-6-nitroquinoline, was obtained via Suzuki reaction. An unexpected side product, 2-(2-methoxyphenyl)-4-methylquinolin-6-amine, was isolated. The structures of the novel compounds were confirmed by 1H, 13C and 2D-NMR. Their optical properties were also studied.

Synthesis of 2-(2-Methoxyphenyl)-4-methyl-6-nitroquinoline and 2-(2-Methoxyphenyl)-4-methylquinolin-6-amine

Key Points

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Implication

Abstract

Discussion

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Synthesis of 2-(2-Methoxyphenyl)-4-methyl-6-nitroquinoline and 2-(2-Methoxyphenyl)-4-methylquinolin-6-amine

Key Points

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Implication

Abstract

Discussion

Cite This Study

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