NUT Carcinoma of the Lacrimal Apparatus Presenting as a Rapidly Enlarging Medial Canthal Mass: A Case Report

Pratiksha Vidhe Sharma; Harshala H. Lokhande; Shruti Vimal

doi:10.1177/10668969261439157

May 4, 2026International Journal of Surgical Pathology

NUT Carcinoma of the Lacrimal Apparatus Presenting as a Rapidly Enlarging Medial Canthal Mass: A Case Report

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Key Points

To report a case of NUT carcinoma presenting as a rapidly enlarging mass in the lacrimal apparatus.
Case report of a young patient with a medial canthal mass
Prompt biopsy with immunohistochemistry was performed
Assessment of tumor markers, including CD99 and NKX2.2
Biopsy confirmed the diagnosis of NUT carcinoma
CD99 and NKX2.2 were negative
Multidisciplinary management highlighted as critical for patient outcomes

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Implication

Case report shows biopsy confirms NUT carcinoma in rapidly enlarging lacrimal apparatus mass, indicating urgency for immunohistochemistry.

Abstract

positivity; CD99 and NKX2.2 were negative-confirming NC.ConclusionLacrimal sac/gland NC should be considered in rapidly enlarging medial canthal masses in young patients. Prompt biopsy with IMMUNOHISTOCHEMISTRY for NUT and early multidisciplinary management are critical.

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Sharma et al. (2026) studied this question.

synapsesocial.com/papers/69fa983604f884e66b53214d https://doi.org/10.1177/10668969261439157

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NUT Carcinoma of the Lacrimal Apparatus Presenting as a Rapidly Enlarging Medial Canthal Mass: A Case Report

Key Points

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Implication

Abstract

Discussion

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NUT Carcinoma of the Lacrimal Apparatus Presenting as a Rapidly Enlarging Medial Canthal Mass: A Case Report

Key Points

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Implication

Abstract

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