Copper catalysed radical cyclization from phenylboronic acid and N-acryloyl indole or benzimidazole derivatives with air as oxidant

Zhuo-Tao Zhang; Shou-Jin Xiao; Yanlong Gu; Minghao Li

doi:10.1039/d6cc01857b

January 1, 2026Chemical Communications

Copper catalysed radical cyclization from phenylboronic acid and N-acryloyl indole or benzimidazole derivatives with air as oxidant

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Key Points

The aim is to develop a copper-catalysed method for radical cyclization using phenylboronic acids.
Utilized copper as a catalyst for radical cyclization
Investigated the use of phenylboronic acid and benzimidazole derivatives
Performed thermochemical oxidation with air as oxidant
Successfully achieved radical cyclization in the presence of copper
Reduced reliance on stoichiometric oxidants such as Mn(OAc)₃ and peroxides
Enhanced practical utility of phenylboronic acid in reactions

Implication

This process demonstrates radical cyclization of phenylboronic acid with benzimidazole derivatives, highlighting an efficient copper catalyst.

Abstract

Thermochemical oxidation of phenylboronic acids to form aryl radicals relies on stoichiometric amounts of Mn(OAc)₃ or peroxides as oxidants, which limits their practical utility. We herein report report the copper-catalysed...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69fa98bd04f884e66b5327be https://doi.org/10.1039/d6cc01857b

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Copper catalysed radical cyclization from phenylboronic acid and N-acryloyl indole or benzimidazole derivatives with air as oxidant

Key Points

Implication

Abstract

Discussion

Cite This Study

Copper catalysed radical cyclization from phenylboronic acid and N-acryloyl indole or benzimidazole derivatives with air as oxidant

Key Points

Implication

Abstract

Discussion

Cite This Study

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