What question did this study set out to answer?

Investigate the effects of continuous kidney replacement therapy on thyroid function and hormone clearance during acute kidney injury and end-stage kidney disease.

May 6, 2026Kidney360Open Access

Thyroid Function with Continuous KRT

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Authors

MKMatthew KennisUniversity of Colorado Anschutz Medical Campus DMDavid MadisonUniversity of Colorado Anschutz Medical Campus NFNorth FoulonUniversity of Colorado Anschutz Medical Campus

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Implication

Observational study finds lower thyroid hormone levels and higher mortality rates in CKRT patients, highlighting severe complications.

Key Points

Investigate the effects of continuous kidney replacement therapy on thyroid function and hormone clearance during acute kidney injury and end-stage kidney disease.
Prospective, single-center observational study
Enrolled 50 ICU patients on CKRT and 50 control ICU patients
Measured serum TSH, fT4, fT3, and rT3 at multiple time points
Employed statistical analyses including linear mixed modelling and ANOVA with FDR correction.
CKRT patients had lower fT4 and fT3 levels compared to controls
TSH and fT4 were detected in CKRT effluent, indicating clearance
Severe and persistent non-thyroidal illness syndrome observed in CKRT cohort
No patients achieved euthyroid status during CKRT

Cite This Study

Kennis et al. (2026) studied this question.

synapsesocial.com/papers/69faa1eb04f884e66b532b6c https://doi.org/10.34067/kid.0000001220

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Thyroid Function with Continuous KRT

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Implication

Key Points

Cite This Study

Thyroid Function with Continuous KRT

Discussion

Member takes

Implication

Key Points

Cite This Study

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