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May 6, 2026ChildrenOpen Access

Early Initiation of rhGH Therapy Significantly Improves Height Gain and Reduces the Gap to Target Height in Children Born Small for Gestational Age: A Multicenter Retrospective Study

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Authors

LMLetteria Anna MorabitoMWMalgorzata WasniewskaCLCecilia Lugarà

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Overview

Multicenter study demonstrates rhGH therapy improves height in children born SGA, suggesting timely treatment benefits.

Key Points

  • To evaluate the impact of rhGH therapy on growth trajectory and adult height in children born small for gestational age.
  • Conducted a multicenter retrospective study with 49 SGA children treated with rhGH and followed over two years.
  • Collected clinical and anthropometric data at multiple time points during treatment and puberty.
  • Performed univariate and multivariate regression analysis to assess predictors of height gain.
  • Significant increase in height gain observed at all evaluated stages (p < 0.05).
  • Height-target height difference decreased significantly particularly in the first two years of puberty.
  • 86% of subjects reached adult height within the target height range.

Cite This Study

Morabito et al. (2026) studied this question.

synapsesocial.com/papers/69faa28f04f884e66b5330cbhttps://doi.org/10.3390/children13050641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of Recombinant Human Growth Hormone Therapy in Small‐for‐Gestational‐Age Children With Short Stature: A Stratified Analysis Based on Genetic Variant Status2026
  2. 2Metabolic and Growth Outcome of Two-year Growth Hormone Treatment in Children Born Small for Gestational Age: A Retrospective Study2024
  3. 3Growth hormone therapy in children born small for gestational age with persistent short stature (SGA-SS): Lessons learned from real-world international databases and directions for future research2026
  4. 4From early growth failure to endocrine recovery: Long-term outcomes and GH therapy in SGA and severely preterm children2025
  5. 5GH–IGF-1 axis and rhGH outcomes in children with GHD, ISS and SGA: a systematic review and meta-analysis2026