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May 6, 2026CancersOpen Access

Piezo1-ATF3-PPP1r15a Axis Transduces Mechanical Stress into Apoptosis in Glioma Under Low-Intensity Focused Ultrasound

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Authors

MLMingming LiWWWeidong WangJJJian Jiang

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Overview

Experiments demonstrate therapeutic effects of low-intensity focused ultrasound on glioma apoptosis, highlighting the role of the ATF3 pathway.

Key Points

  • To evaluate therapeutic effects of low-intensity focused ultrasound on glioblastoma and investigate underlying mechanisms.
  • Evaluated cell viability and proliferation using cell counting kit-8, EdU and colony formation assays.
  • Assessed LIFU effects on apoptosis via flow cytometry.
  • Utilized various techniques including transcriptome sequencing, immunofluorescence, and Western blot to explore molecular mechanisms.
  • Validated therapeutic efficacy using a subcutaneous xenograft tumor model.
  • LIFU activated the Piezo1 and modulated the ATF3 pathway to regulate apoptosis.
  • Demonstrated anti-GBM effects of LIFU were evident through multiple assays and models.
  • LIFU showed potential to improve prognosis for GBM patients.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69faa28f04f884e66b5330f9https://doi.org/10.3390/cancers18091445
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