Key result
Long-term follow-up links American Indian cohorts to rising metabolic risk factors despite ~5% less smoking.
Cohort (n=1,383)
Yes
p-value: p=<0.01
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Over a 22-year follow-up, American Indian populations experienced significant increases in the prevalence of hypertension, diabetes, obesity, and low HDL-C, highlighting a growing burden of cardiovascular risk factors.
Reese et al. (2026) conducted a cohort in Cardiovascular Disease (CVD) Risk Factors (n=1,383). Time (22 years of follow-up) vs. Baseline was evaluated on Changes in the prevalence of major CVD risk factors (p=<0.01). Over 22 years of follow-up in American Indians, the prevalence of hypertension, diabetes, obesity, and low HDL-C significantly increased (all p<0.01), while current smoking decreased by 4.6% (p=0.03).
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