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May 6, 2026PharmaceuticsOpen Access

Pluronic F-127/Propylene Glycol Binary Building Blocks for Novel Solid Dispersion Matrix: Industrial and Ecological Paradigm to Enhance Dissolution Profile of Dapagliflozin

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Authors

ASAbdelrahman Y. SherifKing Saud UniversityMAMohammad A. AltamimiKing Saud UniversityEEEhab M. ElzayatKing Saud University

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Implication

Novel solid dispersion enhances dissolution of dapagliflozin, indicating ecological benefits and efficient methods.

Key Points

  • Evaluate a new solid dispersion matrix for improving dapagliflozin dissolution while addressing ecological and industrial challenges.
  • Formulated solid dispersion of dapagliflozin using the NSDM approach and compared with conventional methods.
  • Utilized heat fusion, microwave, and lyophilization approaches for comparison.
  • Characterized formulations using differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray diffraction.
  • Conducted in vitro dissolution tests to assess performance against conventional methods.
  • NSDM achieved 97.30% dissolution efficiency with 2.40 min mean dissolution time.
  • Displayed unique thermal transition at 32.4 °C and complete liquefaction in 81.7 s.
  • Showed amorphization of dapagliflozin across all formulations.
  • Demonstrated comprehensive advantages in ecological impact, worker friendliness, and industrial effectiveness.

Cite This Study

Sherif et al. (2026) studied this question.

synapsesocial.com/papers/69faa2e204f884e66b53377ahttps://doi.org/10.3390/pharmaceutics18050560
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