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November 12, 2025PharmaceuticsOpen Access

Implementation of a Potential Industrial Green, Economical, and Safe Strategy to Enhance Commercial Viability of Liquid Self-Nanoemulsifying Drug Delivery System

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Authors

ASAbdelrahman Y. SherifMAMohammad A. AltamimiEEEhab M. Elzayat

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Overview

This research shows T-SNEDDS improves drug dissolution and stability in a sustainable way, highlighting the benefits of solidification techniques.

Key Points

  • Optimized T-SNEDDS formulation achieved 95.7% dissolution efficiency for dapagliflozin, much higher than conventional methods.
  • The formulation included 8.60% Pluronic F127, 10% propylene glycol, resulting in optimal particle size of 96.64 nm.
  • Analysis used the Box–Behnken approach to evaluate impacts of ingredients on liquefying temperature and time.
  • T-SNEDDS represents a significant advancement in drug delivery, minimizing environmental concerns through sustainable practices.

Cite This Study

Sherif et al. (2025) studied this question.

synapsesocial.com/papers/69252e8bc0ce034ddc355cf2https://doi.org/10.3390/pharmaceutics17111461
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pluronic F-127/Propylene Glycol Binary Building Blocks for Novel Solid Dispersion Matrix: Industrial and Ecological Paradigm to Enhance Dissolution Profile of Dapagliflozin2026
  2. 2Turmeric oil-fortified nutraceutical-SNEDDS: An approach to boost therapeutic effectiveness of dapagliflozin during treatment of diabetic patients2025 · 3 citations
  3. 3Self-Nanoemulsifying Drug Delivery System: Formulation, Characterization and Solidification Approaches2026 · 1 citations
  4. 4Solid self-nanoemulsifying drug delivery systems of nimodipine: development and evaluation2024 · 18 citations
  5. 5Pluronic F-68 Triblock Copolymer Architecture for a Next-Generation Self-Nanoemulsifying System: Overcoming Drug Trapping and Dosage Challenges of Candesartan Cilexetil2025