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October 18, 2025Open ChemistryOpen Access

Turmeric oil-fortified nutraceutical-SNEDDS: An approach to boost therapeutic effectiveness of dapagliflozin during treatment of diabetic patients

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Authors

EEEhab M. ElzayatKing Saud UniversityASAbdelrahman Y. SherifKing Saud UniversityIAIbrahim AlotaibiKing Saud University

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Implication

Nutraceutical-SNEDDS formulation demonstrates improved dissolution and bioavailability of dapagliflozin, suggesting enhanced therapeutic outcomes.

Key Points

  • The formulation of nutraceutical-SNEDDS significantly improved the dissolution efficiency of dapagliflozin.
  • Optimum drug release was achieved with 88.7% dissolution for S4 formulation, comparable to Forxiga's 90.8%.
  • Characterization revealed successful drug amorphization, ensuring no chemical interactions occurred.
  • The study highlights the potential of turmeric oil to enhance dapagliflozin's bioavailability and therapeutic effectiveness.

Cite This Study

Elzayat et al. (2025) studied this question.

synapsesocial.com/papers/68f3d0c11cb4135751d12c28https://doi.org/10.1515/chem-2025-0200
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