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September 12, 2025ACS OmegaOpen Access

Pluronic F-68 Triblock Copolymer Architecture for a Next-Generation Self-Nanoemulsifying System: Overcoming Drug Trapping and Dosage Challenges of Candesartan Cilexetil

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Authors

ASAbdelrahman Y. SherifMIMohamed Abbas Ibrahim

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Overview

This study shows IL-SNEDDS significantly improves dissolution in candesartan cilexetil formulations, suggesting advantages over traditional SNEDDS.

Key Points

  • IL-SNEDDS enhanced the dissolution of candesartan cilexetil, overcoming traditional solid SNEDDS limitations.
  • The optimum formulation contained 7.5% w/w Pluronic-F-68 with a liquefying temperature of 34 °C.
  • Physicochemical characterization confirmed candesartan cilexetil's presence in an amorphous state, indicating no drug trapping.
  • Compared to S-SNEDDS, IL-SNEDDS showed improved performance without chemical interactions with the drug.

Cite This Study

Sherif et al. (2025) studied this question.

synapsesocial.com/papers/68d44c5531b076d99fa5608bhttps://doi.org/10.1021/acsomega.5c06315
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