Solubility Enhancement of Palbociclib Supersaturable Self-Nano Emulsifying Drug Delivery System by Central Composite Design

This is the authors' abstract. We don't add key points for this paper.

Nowadays, solid self-nano-emulsifying supersaturable drug delivery systems (S-SNEDDS) are being investigated to overcome the limitations of self-nano-emulsifying drug delivery systems (SNEDDS). The current study established S-SNEDDS for better drug dissolution and stability. S-SNEDDS were made with saturated solubility capryol® 90, labrosol®, and transcutol® HP. The composition was optimized using ternary phase diagrams. Palbociclib-SNEDDS created droplet size (Y1), polydispersity index (PDI) (Y2), and 15-minute drug release (Y3) responses using the central composite design (CCD) of response surface methodology (RSM). To optimise SNEDDS (S1) and evaluate S-SNEDDS, several precipitation inhibitors (PIs) were introduced. The best formulation, S1, had a minimum particle size of 129.34 nm and a maximum zeta potential (ZP) of 28.6 ± 2.12 mV. Unlike other inhibitors, methylcellulose kept the medicine supersaturated. The optimized formulation (F3) had a higher ZP (-24.6 ±1.8 mV) and smaller particle size (118.42 ± 1.26 nm), making it more stable than regular SNEDDS amorphous palbociclib was found in S-SNEDDS utilizing differential scanning calorimetry (DLS) and X-ray powder diffraction (PXRD). F3 released >99% in 90 minutes, compared to 19% for pure drug dispersion and 95% for SNEDDS. Results showed that S-SNEDDS formulation improved palbociclib solubility and stability.