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September 10, 2026Journal of Applied Pharmaceutical ScienceOpen Access

Design, Optimization, and Characterization of Nilotinib-loaded Supersaturable Self-nanoemulsifying Drug Delivery Systems for Improved Anticancer Efficacy

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Authors

VPVyshali ParigelaVAVijayalakshmi Arumugam

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Overview

In vitro formulation study demonstrates enhanced dissolution and stability of nilotinib via supersaturable nanoemulsions, suggesting improved oral bioavailability.

Key Points

  • To design, optimize, and characterize a supersaturable self-nanoemulsifying drug delivery system (sSNEDDS) to overcome the poor aqueous solubility and dissolution limitations of nilotinib.
  • Formulated sSNEDDS utilizing castor oil, Kolliphor EL, propylene glycol, and HPMC K4M as a precipitation inhibitor, using a Box–Behnken experimental design for optimization.
  • Evaluated the formulation through droplet size analysis, entrapment efficiency, FTIR, XRPD, DSC, a six-month thermodynamic stability assessment, and in vitro dissolution kinetics.
  • The optimized sSNEDDS achieved an average droplet size of 105.87 nm, a polydispersity index of 0.069, an entrapment efficiency of 87.23%, and maintained stability over six months.
  • In vitro dissolution yielded greater than 90% drug release within 720 minutes, demonstrating anomalous (non-Fickian) release kinetics that substantially exceeded conventional formulations.

Cite This Study

Parigela et al. (2026) studied this question.

synapsesocial.com/papers/6aaa01a920cf838608fbc63fhttps://doi.org/10.1177/22313354261472048
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