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May 6, 2026European Heart JournalOpen Access

Each hs-troponin assay (log-transformed, per 1 SD) was independently associated with all-cause mortality (e.g., HR 1.31, 95% CI 1.21-1.42 for Roche hs-TnT) and cardiovascular mortality (HR 1.44 to 1.65 per 1 SD).

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Why the study?

Cardiac troponin T and I can be measured using multiple high-sensitivity assays, but their correlations and comparative associations with mortality needed characterization.

Are different high-sensitivity troponin assays associated with all-cause and cardiovascular mortality in adults without cardiovascular disease?

Population

9810 adults without cardiovascular disease in the 1999-2004 NHANES

Comparison

Four hs-troponin assays: hs-troponin T (Roche) vs three hs-troponin I assays (Abbott, Siemens, Ortho)

Design

Cohort study using Cox regression analysis

Authors

JMJohn W. McEvoyNDNatalie DayaOTOlive Tang

Discussion

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Member takes

Overview

May identify higher-risk patients for closer monitoring; leaves open whether hs-troponin testing improves clinical outcomes.

Structured PICO

Are different high-sensitivity troponin assays associated with all-cause and cardiovascular mortality in adults without cardiovascular disease?

P
Population
9,810 adults without cardiovascular disease from the 1999-2004 National Health and Nutrition Examination Survey
I
Intervention
Measurement of high-sensitivity troponin T (Roche) and high-sensitivity troponin I (Abbott, Siemens, Ortho)
O
Outcome
All-cause mortality and cardiovascular mortalityhard clinical

Different high-sensitivity troponin assays show only modest correlation but independently predict all-cause and cardiovascular mortality in the general population.

Cite This Study

McEvoy et al. (2023) studied this question.

synapsesocial.com/papers/69fab32dbe8db9224745365ahttps://doi.org/10.1093/eurheartj/ehad328
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