Cross-cohort comparison shows wrist circumference-dependent thresholds classify median nerve area in CTS patients, implying broader applicability.
Background: Considerable between-center variability exists in the upper limit of normal (ULN) for the cross-sectional area (CSA) of the median nerve (MN) used to support the diagnosis of carpal tunnel syndrome (CTS). Objective: To evaluate whether a Dutch wrist circumference-dependent (WCD) equation for the ULN of MN CSA provides comparable classification of abnormal CSA in Italian and Dutch CTS populations. Methods: as WC in cm). Findings were compared with electrodiagnostic results. Results: < 0.0001). Conclusion: The WCD ULN for MN CSA yielded similar results in Italian and Dutch patients with CTS, and may be particularly useful in individuals with smaller wrists.
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Dubbelink et al. (2026) studied this question.
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