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This review aims to synthesize current understanding of DAMPs in the context of immunogenic cell death and their roles in cancer therapy.

May 6, 2026CancersOpen Access

Danger or Salvation? The Role of DAMPs in Cancer Therapy

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This review aims to synthesize current understanding of DAMPs in the context of immunogenic cell death and their roles in cancer therapy.
Systematically reviewed literature on immunogenic cell death and DAMPs from Pubmed and Google Scholar.
Categorized DAMPs based on recognition mechanisms into five classes and cellular origins: extracellular, mitochondrial, nuclear, and cytosolic.
Analyzed key molecules, receptors, signaling pathways, and clinical associations.
DAMPs release enhances dendritic cell maturation and activation of cytotoxic T lymphocytes, aiding tumor cell elimination.
DAMPs can induce sterile inflammation necessary for antitumor immunity but may also promote metastasis and chronic inflammation.
High-mobility group box 1 (HMGB1) and calreticulin (CRT) show the strongest prognostic value among DAMPs.

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Review summarizes DAMPs’ mechanisms and significance in cancer therapy, highlighting implications for immunotherapy.

Vedunova et al. (2026) studied this question.

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