What question did this study set out to answer?

This research aims to develop new synthetic methods for N–N linked indolyl quinazolinones using a novel approach.

May 6, 2026Synthesis0 citations

Synthesis of N–N Linked Indolyl Quinazolinones via De Novo Construction of the Quinazolinone Ring

ZSZhu-Di ShuJiangsu Normal University SGShuo GaoJiangsu Normal University MMMing-Yi MaJiangsu Normal University

Key Points

This research aims to develop new synthetic methods for N–N linked indolyl quinazolinones using a novel approach.
Established a Brønsted acid-catalyzed (5 + 1) annulation/oxidation cascade.
Utilized indole-derived 2-aminobenzamides and aldehydes in the synthesis process.
Produced structurally diverse N–N linked heterobiaryl indoles.
Achieved excellent yields of up to 99% in the synthesis process.
Expanded the library of N–N linked heterobiaryl indoles.
Demonstrated potential biological utility of the newly synthesized compounds.

Abstract

Abstract A class of six-membered heterobiaryl indoles, N–N linked indolyl quinazolinones, has been accessed via the de novo construction of the quinazolinone ring. Addressing the scarcity of synthetic methods for N–N linked six-membered heterobiaryl indoles, a Brønsted acid-catalyzed (5 + 1) annulation/oxidation cascade of indole-derived 2-aminobenzamides and aldehydes was established. This protocol affords a structurally diverse library of N–N linked heterobiaryl indoles in excellent yields (up to 99%). This work enriches the extensive family of N–N linked heterobiaryl indoles with a new member possessing potential biological utility.

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