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December 1, 1994New England Journal of Medicine

Atherosclerotic Disease of the Aortic Arch and the Risk of Ischemic Stroke

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Key Points

This study aims to determine the association between atherosclerotic disease of the aortic arch and the risk of ischemic stroke.
Conducted a prospective case-control study with 250 patients with ischemic stroke and 250 controls aged over 60.
Used transesophageal echocardiography to assess the frequency and thickness of atherosclerotic plaques.
Adjusted for atherosclerotic risk factors in analyses.
14.4% of patients had plaques ≥4 mm thick vs. 2% in controls; odds ratio for ischemic stroke 9.1 (95% CI, 3.3-25.2; P<0.001).
28.2% of patients with unexplained brain infarcts had plaques ≥4 mm thick; odds ratio 4.7 (95% CI, 2.2-10.1; P<0.001).
Thicker plaques (>3.9 mm) more frequently associated with carotid stenosis ≥70% than thinner plaques.

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Implication

Case-control study quantifies ischemic stroke risk related to aortic arch atherosclerotic disease in older adults, suggesting significant implications for stroke prevention.

Cite This Study

Amarenco et al. (1994) studied this question.

synapsesocial.com/papers/69fbd7fa6c3a0c248625ddec https://doi.org/10.1056/nejm199412013312202

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