Key result
Atherosclerotic plaques ≥4 mm thick in the aortic arch independently predicted recurrent brain infarction (RR 3.8; 95% CI 1.8-7.8; P=0.0012) in patients aged ≥60 with prior brain infarction.
Why the study?
Does atherosclerotic plaque in the aortic arch predict recurrent brain infarction and vascular events in patients 60 years of age or older with prior brain infarction?
Population
331 patients 60 years of age or older who were consecutively admitted to the hospital with brain infarction.
Comparison
Atherosclerotic plaques in the aortic arch… vs Aortic wall thickness < 1 mm and 1 to 3.9 mm.
Design
Cohort
Follow-up
2 to 4 years (788 person-years)
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May refine secondary prevention risk stratification in older stroke patients; leaves open whether targeted therapy improves outcomes.
Cohort (n=331)
Does atherosclerotic plaque in the aortic arch predict recurrent brain infarction and vascular events in patients 60 years of age or older with prior brain infarction?
Relative Risk: 3.8 (95% CI 1.8–7.8)
Absolute Event Rate: 11.9% vs 2.8%
p-value: p=0.0012
Atherosclerotic plaques ≥ 4 mm thick in the aortic arch are significant independent predictors of recurrent brain infarction and other vascular events in older patients with prior stroke.
A 1996 study conducted a cohort in Brain infarction (n=331). Atherosclerotic plaques ≥ 4 mm thick in the aortic arch vs. Aortic-wall thickness < 4 mm was evaluated on Recurrent brain infarction (RR 3.8, 95% CI 1.8 to 7.8, p=0.0012). Atherosclerotic plaques ≥4 mm thick in the aortic arch independently predicted recurrent brain infarction (RR 3.8; 95% CI 1.8-7.8; P=0.0012) in patients aged ≥60 with prior brain infarction.
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