This research aims to understand the role of eosinophil-derived COX-2 in regulating IL-22 during colitis.
Investigated the eosinophil-ILC3 cross talk
Examined COX-2 effects on IL-22 production
Utilized experimental models of colitis
Eosinophil-derived COX-2 modulates IL-22 production
Cross talk between eosinophils and ILC3 is beneficial
Protection of intestinal barrier observed in model of colitis
Abstract
as a critical regulator of IL-22 production during colitis, uncovering a eosinophil-ILC3 cross talk that safeguards the intestinal barrier and represents a promising therapeutic target in IBD.