⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

April 30, 2026Endocrine Metabolic & Immune Disorders - Drug Targets

Gut Microbiota Mediates the Relationship BetweenImmune Cells and Familial Hypercholesterolemia:A Mendelian Randomization Study

Shuwei Liang Zeyu Zhou Siming Wang Qian Xue Aoni Wu Haopeng Yang Qiyu Sun

View at Publisher

Ask AI

Bookmark

Share

Key Points

The study investigates the causal effects of immune cells on familial hypercholesterolemia (FH) and assesses the mediating role of gut microbiota.
Two-sample Mendelian Randomization analysis
Utilized single-nucleotide polymorphisms as instrumental variables from GWAS
Employed Inverse-Variance Weighted method for causal effect estimation
Supplemented with MR-Egger and weighted median methods for validation
Assured validity of instrumental variables through heterogeneity and pleiotropy tests
Identified 34 immune cell traits and 12 gut microbiota taxa associated with FH
19 immune cells were inversely associated with FH risk while 15 were positively associated
Six gut microbiota taxa had inverse associations and six positive associations with FH risk
Mediation analysis found five gut microbial taxa partially mediating the relationship between immune cells and FH

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Mendelian randomization study links gut microbiota and immune cells to familial hypercholesterolemia, suggesting mediation effects.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/69fbe382164b5133a91a2b08 https://doi.org/10.2174/0118715303441505260410094518

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Immune cells and blood lipids mediation: a Mendelian randomization study on metabolic dysfunction-associated fatty liver disease2024
2Causal relationship between the gut microbiota, immune cells, and coronary heart disease: a mediated Mendelian randomization analysis2024 · 5 citations
3Mediating Role of Blood Metabolites in the Relationship Between Immune Cell Traits and Heart Failure: A Mendelian Randomization and Mediation Analysisother · 2025 · 5 citations
4Effect of immune cells and plasma metabolites on inflammatory bowel disease: Two-sample Mendelian randomization study and mediation analysis2025
5Gut microbiome, immune cells and heart failure: a multi-omics Mendelian randomization studyother · 2026

More related papers

Immune-gut-metabolite Interactions in Multiple Sclerosis: A MendelianRandomization and Mediation Study2026
Plasma metabolome mediates the causal relationship between immune cells and heart failure: a two-step bidirectional Mendelian randomization study2024
Role of myeloid cells in mediating the effects of lipids on ulcerative colitis2024

More from Endocrine Metabolic & Immune Disorders - Drug Targets

Multi-omics Mendelian Randomization Prioritizes Neutrophil Extracellular Trap-related Genes Associated with Atrial Fibrillation RiskFri,
Identifying the Oxidative Stress-related Hub Genes in Dilated Cardiomyopathy by Bioinformatics AnalysisMon,