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This research aims to clarify the role of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.

May 7, 2026Cancer ResearchOpen Access

Cancer-Associated Fibroblasts Promote Epithelial-Mesenchymal Transition and Classical to Basal Subtype Shift in Pancreatic Cancer

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Research shows CAFs promote epithelial-mesenchymal transition in pancreatic cancer, suggesting CAF signaling alters tumor classification.

This research aims to clarify the role of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma.
Multi-omic analyses of tumor microenvironment in PDAC patients
Establishment of matched tumor organoid and CAF lines
Functional validation of CAF effects on tumor cells
CAFs promoted epithelial-mesenchymal transition in tumor cells
Shift from classical to basal tumor cell classification observed
IL-8 identified as a modulator of tumor cell subtype

Belanger et al. (2026) studied this question.

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