What question did this study set out to answer?

To review the multifaceted and context-dependent roles of cancer-associated fibroblasts within the pancreatic ductal adenocarcinoma microenvironment across cancer initiation, progression, and treatment response.

January 5, 2025Cellular SignallingOpen Access

The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

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To review the multifaceted and context-dependent roles of cancer-associated fibroblasts within the pancreatic ductal adenocarcinoma microenvironment across cancer initiation, progression, and treatment response.
Literature review assessing preclinical and clinical evidence regarding the tumor microenvironment in pancreatic ductal adenocarcinoma.
Synthesis of mechanistic evidence on cancer-associated fibroblast heterogeneity, signaling networks, and therapeutic targeting strategies.
Cancer-associated fibroblasts represent a heterogeneous cellular population capable of either restraining or promoting pancreatic cancer growth depending on the biological context.
Fibroblast signaling and stroma remodeling drive pancreatic cancer progression, metastasis, and immune evasion.
Therapeutic strategies aimed at modulating or targeting specific cancer-associated fibroblast subpopulations present promising avenues to overcome therapy resistance.

Authors

JKJohn Y. KwonMayo Clinic RVRenzo E. VeraMayo Clinic MFMartín E. Fernández-ZapicoToyota Motor Corporation (Switzerland)

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Implication

Narrative review uncovers dual tumor-suppressive and tumor-promoting functions of cancer-associated fibroblasts in pancreatic cancer, highlighting their potential as targets for novel therapies.

Cite This Study

Kwon et al. (2025) studied this question.

synapsesocial.com/papers/6a75c3aef1e99ff85ab212de https://doi.org/10.1016/j.cellsig.2024.111584

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Implication

Narrative review uncovers dual tumor-suppressive and tumor-promoting functions of cancer-associated fibroblasts in pancreatic cancer, highlighting their potential as targets for novel therapies.

The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

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Discussion

Implication

Cite This Study

The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

Key Points

Discussion

Implication

Cite This Study

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