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Retrospective case series reveals neuroendocrine differentiation in breast tumors does not imply distinct behavior, suggesting it is part of the luminal spectrum.
In our study, breast tumors with neuroendocrine features exhibited a luminal immunophenotype and did not demonstrate a clearly distinct clinical behavior compared with conventional hormone receptor positive breast cancer. Neuroendocrine differentiation may therefore represent a morphological feature within the luminal spectrum rather than a distinct biological entity.
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Gavrilescu et al. (2026) studied this question.
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