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This study explores the relationship between psychosis spectrum status and cardiometabolic biomarkers at midlife.

Cardiometabolic Biomarkers at Age 44-45 in the Psychosis Spectrum: The British National Child Development Study

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This study explores the relationship between psychosis spectrum status and cardiometabolic biomarkers at midlife.
Analyzed data from the British National Child Development Study biomedical sweep (n = 9377) at age 44-45.
Defined psychosis spectrum status through self-reported diagnoses and medication use across adulthood.
Compared cardiometabolic biomarkers between psychosis spectrum individuals and controls, with adjustments for early-life adversity.
Individuals on the psychosis spectrum showed worse cardiometabolic profiles than controls.
Significantly elevated abdominal obesity (1.404 times), higher glycated hemoglobin, and lower high-density lipoprotein cholesterol were observed.
Increased fibrinogen was also noted among those on the psychosis spectrum compared to psychosis-free individuals.

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Population-based analysis reveals psychosis spectrum correlates with elevated cardiometabolic risks, indicating treatment needs.

Kravariti et al. (2026) studied this question.

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