Metal-Coordination-Driven Self-Assembly of 8-Hydroxyquinoline-Peptide into Hybrid Nanomaterials for In Vitro Multimodal Synergistic Anticancer Activity

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This is a In Vitro Study study.

Xin Tian; Xinming Li; Shengyao Wang

doi:10.1039/d6ob00498a

January 1, 2025Organic & Biomolecular Chemistry

Metal-Coordination-Driven Self-Assembly of 8-Hydroxyquinoline-Peptide into Hybrid Nanomaterials for In Vitro Multimodal Synergistic Anticancer Activity

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Key Points

The research aims to explore the anticancer potential of hybrid nanomaterials formed from 8-hydroxyquinoline and peptides.
Developed hybrid nanomaterials through metal-coordination-driven self-assembly of 8-hydroxyquinoline and peptides.
Assessed the biocompatibility and pharmacological activities of the synthesized nanomaterials in vitro.
Evaluated the multimodal synergistic effects against cancer cells.
Demonstrated high biocompatibility of the hybrid nanomaterials.
Achieved multimodal anticancer activity in vitro, indicating effectiveness against cancer cells.
Showed enhanced pharmacological activities compared to individual components.

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Implication

Hybrid nanomaterials based on 8-hydroxyquinoline demonstrate multimodal anticancer activity, highlighting their pharmacological potential.

Abstract

Hybrid nanomaterials based on 8-hydroxyquinoline (8-HQ) metal complexes represent a promising class of therapeutic platforms, combining high biocompatibility with diverse pharmacological activities. Leveraging the strong bidentate metal-chelating ability of 8-HQ,...

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Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/69fbefd5164b5133a91a3d90 https://doi.org/10.1039/d6ob00498a

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Metal-Coordination-Driven Self-Assembly of 8-Hydroxyquinoline-Peptide into Hybrid Nanomaterials for In Vitro Multimodal Synergistic Anticancer Activity

Key Points

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Implication

Abstract

Discussion

Cite This Study

Metal-Coordination-Driven Self-Assembly of 8-Hydroxyquinoline-Peptide into Hybrid Nanomaterials for In Vitro Multimodal Synergistic Anticancer Activity

Key Points

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Implication

Abstract

Discussion

Cite This Study

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