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This research examines the relationship between metabolic health and antiretroviral therapy in youth living with perinatally acquired HIV.

May 7, 2026AIDS

Risk factors associated with adverse metabolic health in youth with perinatally acquired HIV living in the United Kingdom

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This research examines the relationship between metabolic health and antiretroviral therapy in youth living with perinatally acquired HIV.
Longitudinal observational cohort study over 26 months
85 youth with perinatally acquired HIV assessed for metabolic health
Evaluated using fasting biochemistry, body mass index, dual energy x-ray absorptiometry, and hepatic transient elastography
Gathered data on ART exposure, CD4 count, and viral load
Mean age of participants was 21.7 years, 58% female and 82% black African
Median weight gain over 26 months was 3 kg; BMI category overweight/obese increased from 37% to 50%
48% of participants showed dyslipidaemia; metabolic syndrome criteria met by 7%
13% had hypertension, 18% with hepatic steatosis, and 7% fibrosis on transient elastography
No association found between integrase strand transfer inhibitor and/or tenofovir alafenamide use and metabolic outcomes

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Longitudinal cohort study reveals adverse metabolic health amid youth with HIV, suggesting need for preventive interventions.

Foster et al. (2026) studied this question.

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