What is the clinical evidence from this study?

Study design: Cohort. Population: Perinatally acquired HIV (n=98). Intervention: Perinatally acquired HIV vs. Matched controls. Primary outcome: Lipid and lipoprotein levels over time (p=> 0.05).

What does this research mean for the field?

Youth with perinatally acquired HIV on combination antiretroviral therapy exhibit long-term lipid and lipoprotein profiles comparable to matched controls, although protease inhibitor use is linked to adverse lipid alterations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Evaluate 10-year lipid and lipoprotein trajectories in youth with perinatally acquired HIV compared to matched controls, and determine associations with antiretroviral therapy and metabolic risk markers.

October 24, 2025Lipids in Health and DiseaseOpen Access

Long-term lipoprotein and lipid profiles and association with metabolic risk markers in youth with perinatally acquired HIV and matched controls: a 10-year comparative cohort study

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Key result

Perinatally acquired HIV on cART shows no significant difference in long-term lipid profiles vs. controls.

P>0.05
n=98

Why the study?

Do youth with perinatally acquired HIV on cART have different lipid and lipoprotein profiles over time compared to matched controls?

Key Points

Evaluate 10-year lipid and lipoprotein trajectories in youth with perinatally acquired HIV compared to matched controls, and determine associations with antiretroviral therapy and metabolic risk markers.
Comparative cohort evaluated 32 youth with perinatally acquired HIV (median age 21.7 years) and 36 matched controls (median age 21.2 years) across three time points in 2013, 2018, and 2023.
Cross-sectional evaluation in 2023 included 53 youth with HIV (median age 17.4 years) and 45 controls (median age 19.1 years).
Measured lipoprotein(a), apolipoprotein B, triglycerides, LDL cholesterol, HDL cholesterol, total cholesterol, and metabolic syndrome risk markers.
No significant differences in lipid or lipoprotein levels were observed over time (p > 0.05), though triglycerides were significantly higher in youth with HIV at the second assessment (p = 0.043).
Higher lipoprotein(a) levels correlated with higher LDL-C and apolipoprotein B, but this association was significantly weakened in youth with HIV; protease inhibitor use was associated with higher total cholesterol, triglycerides, and LDL-C.
Cross-sectional analysis showed comparable lipid profiles and metabolic syndrome markers between youth with HIV and controls (p > 0.05).

Study Design

Type

Cohort (n=98)

Structured PICO

Do youth with perinatally acquired HIV on cART have different lipid and lipoprotein profiles over time compared to matched controls?

Population

98 youth with perinatally acquired HIV and matched controls evaluated for lipid and lipoprotein profiles over a 10-year period.

Exposure

Perinatally acquired HIV infection treated with combination anti-retroviral therapy (cART)

Comparator

Matched controls without HIV

Outcome

Lipid and lipoprotein levels (Lp(a), ApoB, TG, LDL-C, HDL-C, TC) and metabolic syndrome markers over 10 yearssurrogate

Main Result

p-value: p=> 0.05

Discussion

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Implication

Youth with perinatally acquired HIV on cART have similar long-term lipid and lipoprotein profiles compared to matched controls, suggesting their increased CVD risk may be driven by other HIV- or treatment-related mechanisms.

Cite This Study

Post et al. (2025) conducted a cohort in Perinatally acquired HIV (n=98). Perinatally acquired HIV vs. Matched controls was evaluated on Lipid and lipoprotein levels over time (p=> 0.05). Youth with perinatally acquired HIV on cART had similar long-term lipid and lipoprotein levels compared to matched controls (p > 0.05), though protease inhibitor use was associated with lipid alterations.

synapsesocial.com/papers/6a19c2a73f3ec013f0df06be https://doi.org/10.1186/s12944-025-02718-z

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Long-term lipoprotein and lipid profiles and association with metabolic risk markers in youth with perinatally acquired HIV and matched controls: a 10-year comparative cohort study

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Long-term lipoprotein and lipid profiles and association with metabolic risk markers in youth with perinatally acquired HIV and matched controls: a 10-year comparative cohort study

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

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