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May 7, 2026Pediatric Blood & CancerOpen Access

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

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Authors

GBGaia BrunettiGPGiorgio PersanoCGChiara Grimaldi

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Overview

Retrospective review of invasive procedures in pediatric patients with GI GVHD shows significant morbidity and mortality risks.

Key Points

  • To evaluate the role of invasive procedures in treating complicated gastrointestinal graft-versus-host disease in pediatric patients.
  • Retrospective review of pediatric patients diagnosed with complicated GI GVHD between 2010 and 2024.
  • Defined complicated GI GVHD as biopsy-proven with surgical symptoms such as severe bleeding and obstruction.
  • Assessed outcomes including need for surgery, angioembolization, mortality, and chronic intestinal failure rates.
  • Eighteen pediatric patients were included; 78% had severe bleeding, 44% with obstruction, and 17% with pneumatosis intestinalis.
  • Five patients underwent invasive procedures: four had surgery for obstruction; one had angioembolization for severe bleeding.
  • Postoperative morbidity was high, with chronic intestinal failure occurring in 80% of surgical cases.

Cite This Study

Brunetti et al. (2026) studied this question.

synapsesocial.com/papers/69fbf004164b5133a91a43d3https://doi.org/10.1002/1545-5017.70379
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Also Consider

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  1. 1CURRENT PERSPECTIVES ON THE MANAGEMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE IN PEDIATRIC TRANSPLANTATION2025
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  3. 3Intestinal and Extraintestinal Findings of Graft-versus-Host Disease on CT: A Case Series with Radiological and Histopathological Correlations2024 · 5 citations
  4. 4The Treatment of Steroid-Refractory Severe Gastrointestinal Acute Graft-Versus-Host Disease in Children after Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Centre Experience2024
  5. 5A Case Report of Refractory Graft-Versus-Host Disease Colitis Managed With Robotic Total Abdominal Colectomy2024 · 1 citations