What type of study is this?

This is a Cohort Study study (also classified as: Pre-Registered Trial).

What question did this study set out to answer?

This study aims to characterize the intraoperative dynamics of coagulation factors during liver transplantation to understand hemostatic changes.

May 7, 2026Perioperative MedicineOpen Access

Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study

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Authors

STSarah ThalerLMU Klinikum AZAnna ZornLMU Klinikum IAIsabell AsterLMU Klinikum

Discussion

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Implication

Prospective analysis uncovers hemostatic changes in coagulation factors during liver transplantation, suggesting individualized interventions may enhance patient outcomes.

Key Points

This study aims to characterize the intraoperative dynamics of coagulation factors during liver transplantation to understand hemostatic changes.
Analyzed 17 liver transplant recipients receiving transfusion support.
Measured coagulation factors V, VIII, and XIII at three intraoperative time points.
Quantified activities of coagulation factors and analyzed for trends.
All three coagulation factors declined during surgery.
Factor V decreased from 37% at T1 to 26% at T3.
Factor VIII showed supranormal levels at T1, falling to near-normal at T3.
Factor XIII levels remained stable and close to the lower limit of normal.

Cite This Study

Thaler et al. (2026) studied this question.

synapsesocial.com/papers/69fbf004164b5133a91a443c https://doi.org/10.1186/s13741-026-00695-0

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Implication

Prospective analysis uncovers hemostatic changes in coagulation factors during liver transplantation, suggesting individualized interventions may enhance patient outcomes.

Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Phase-specific dynamics of coagulation factors V, VIII, and XIII during liver transplantation: insights from a prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

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