What question did this study set out to answer?

To characterize continuous thrombin generation and antithrombin activity across sequential phases of orthotopic liver transplantation.

April 28, 2009Haemostasis

Prothrombin Fragment 1+2 and Thrombin-Antithrombin Complex Measurements Indicate Continuous and Progressive Intraoperative Thrombin Generation in Liver Transplantation

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Authors

APArturo PereiraServices Hospital JPJosefina Pijoan JBJaime Balust

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Implication

Observational study reveals progressive thrombin generation throughout liver transplantation, indicating early coagulation activation and heightened plasma requirements.

Key Points

To characterize continuous thrombin generation and antithrombin activity across sequential phases of orthotopic liver transplantation.
Prospective study of 40 patients undergoing 43 orthotopic liver transplantations.
Serial intraoperative measurements of prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT), and antithrombin III (ATIII) were evaluated before surgery, at the end of the anhepatic phase, and after graft reperfusion.
F1+2 and TAT levels rose continuously from preoperative baselines (1.47 ± 0.92 nmol/l and 22.41 ± 19.15 ng/ml) to the end of the anhepatic phase (5.97 ± 2.20 nmol/l and 64.24 ± 11.30 ng/ml), increasing further after reperfusion (6.87 ± 1.65 nmol/l and 89.32 ± 7.54 ng/ml).
Circulating ATIII levels fell significantly post-reperfusion from 70.61 ± 12.28% to 57.16 ± 9.57%, whereas changes during earlier phases were negligible.
Elevated preoperative F1+2 was associated with higher requirements for packed red blood cells and fresh frozen plasma during explantation, and lower basal ATIII correlated with greater overall intraoperative plasma use.

Cite This Study

Pereira et al. (2009) studied this question.

synapsesocial.com/papers/6aa92601d0c7c778ac8cb59d https://doi.org/10.1159/000216852

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Implication

Observational study reveals progressive thrombin generation throughout liver transplantation, indicating early coagulation activation and heightened plasma requirements.

Prothrombin Fragment 1+2 and Thrombin-Antithrombin Complex Measurements Indicate Continuous and Progressive Intraoperative Thrombin Generation in Liver Transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Prothrombin Fragment 1+2 and Thrombin-Antithrombin Complex Measurements Indicate Continuous and Progressive Intraoperative Thrombin Generation in Liver Transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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