Ventricular remodeling in active myocarditis
Why the study?
Does active myocarditis affect left ventricular geometry and remodeling compared to normal controls?
Structured PICO
Does active myocarditis affect left ventricular geometry and remodeling compared to normal controls?
P
Population
35 patients with biopsy-confirmed myocarditis and 20 normal controls (total n=55)
C
Comparator
Normal controls
O
Outcome
Left ventricular geometry (end-diastolic volume, long axis length, mid-cavity diameter, degree of sphericity) and left ventricular ejection fractionsurrogate
Active myocarditis is associated with early left ventricular remodeling, characterized by chamber dilatation and increased sphericity, which correlates with reduced ejection fraction.
Authors
Discussion
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Implication
Active myocarditis may drive early LV dilatation and sphericity; this case-control finding is hypothesis-generating and requires prospective validation.
Cite This Study
Mendes et al. (1999) studied this question.