April 5, 2006Current Opinion in Cardiology
The role of molecular autopsy in unexplained sudden cardiac death
Why the study?
Does molecular autopsy identify pathogenic mutations in young people and infants with autopsy-negative sudden unexplained death?
Population
Young people and infants with autopsy-negative sudden unexplained death or sudden infant death syndrome
Design
Review
Authors
Discussion
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Member takes
Implication
May support family screening after SUD/SIDS; leaves open prospective validation before routine adoption.
Structured PICO
Does molecular autopsy identify pathogenic mutations in young people and infants with autopsy-negative sudden unexplained death?
P
Population
Young people and infants with autopsy-negative sudden unexplained death (SUD) or sudden infant death syndrome (SIDS)
I
Intervention
Molecular autopsy (post-mortem cardiac channel genetic testing)
O
Outcome
Identification of pathogenic mutations responsible for sudden unexplained death
Molecular autopsy is a valuable tool for identifying pathogenic cardiac channel mutations in cases of autopsy-negative sudden unexplained death, guiding pre-emptive strategies for surviving family members.
Cite This Study
Tester et al. (2006) studied this question.