Why the study?
How do epicardial repolarisation gradients relate to the configuration of the T wave in patients with upright versus inverted T waves?
How do epicardial repolarisation gradients relate to the configuration of the T wave in patients with upright versus inverted T waves?
Epicardial repolarisation gradients exist in humans and determine T wave configuration, with T wave inversion associated with a loss of the normal inverse relationship between action potential duration and activation time.
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Supports role of repolarisation gradients in T-wave polarity; hypothesis-generating for ECG risk markers and needs prospective validation.
Cowan et al. (1988) studied this question.
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