November 1, 2004Psychosomatic Medicine
Prognostic Association of Depression Following Myocardial Infarction With Mortality and Cardiovascular Events: A Meta-analysis
Why the study?
Does post-MI depression increase the risk of mortality and cardiovascular events in patients with myocardial infarction?
Population
6,367 patients with myocardial infarction (pooled from 22 papers / 16 prospective cohorts)
Comparison
Post-MI depression vs Patients without post-MI depression
Design
Meta-analysis
Follow-up
average 13.7 months
Authors
Discussion
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Member takes
Implication
Supports routine post-MI depression screening; reinforces its prognostic link to mortality in cardiac populations.
Structured PICO
Does post-MI depression increase the risk of mortality and cardiovascular events in patients with myocardial infarction?
P
Population
6,367 patients with myocardial infarction (pooled from 22 papers / 16 prospective cohorts)
I
Intervention
Post-MI depression (assessed within 3 months after MI using established psychiatric instruments)
C
Comparator
Patients without post-MI depression
O
Outcome
Mortality (all-cause and cardiac) and new cardiovascular events within 2 years from index MIhard clinical
Post-MI depression is associated with a 2- to 2.5-fold increased risk of all-cause mortality, cardiac mortality, and new cardiovascular events.
Cite This Study
Melle et al. (2004) studied this question.