What question did this study set out to answer?

To investigate whether depressive symptoms represent an independent risk factor for incident coronary heart disease and total mortality in an initially healthy elderly cohort.

October 10, 2000CirculationOpen Access

Depressive Symptoms and Risks of Coronary Heart Disease and Mortality in Elderly Americans

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Why the study?

Do depressive symptoms increase the risk of coronary heart disease and mortality in elderly Americans free of cardiovascular disease?

Key Points

To investigate whether depressive symptoms represent an independent risk factor for incident coronary heart disease and total mortality in an initially healthy elderly cohort.
Analyzed 4,493 participants aged ≥65 years free of cardiovascular disease at baseline from the Cardiovascular Health Study (total N=5,888) with up to 6 years of follow-up.
Assessed depressive symptoms annually using the Center for Epidemiological Studies Depression Scale to calculate cumulative mean depression scores.
Estimated risks of coronary heart disease (CHD) and all-cause mortality using time-dependent proportional-hazards models adjusted for cardiovascular and demographic covariates.
Every 5-unit increase in cumulative mean depression score was associated with incident CHD (unadjusted HR 1.15, P=0.006; adjusted HR 1.15, P=0.006) and all-cause mortality (unadjusted HR 1.29, P<0.0001; adjusted HR 1.16, P=0.006).
Participants in the highest cumulative mean depression score category experienced a 40% increased risk of CHD and a 60% increased risk of all-cause mortality compared with those in the lowest category.

Structured PICO

Do depressive symptoms increase the risk of coronary heart disease and mortality in elderly Americans free of cardiovascular disease?

Population

4,493 elderly Americans (≥65 years) free of cardiovascular disease at baseline, enrolled in the Cardiovascular Health Study

Intervention

Higher cumulative mean depression score (assessed annually using the Depression Scale of the Center for Epidemiological Studies)

Comparator

Lower cumulative mean depression score

Outcome

Development of coronary heart disease (CHD) and total mortalityhard clinical

Depressive symptoms are an independent risk factor for the development of coronary heart disease and total mortality in elderly Americans.

Discussion

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Implication

May inform risk assessment in elderly Americans; extends observational evidence on depression and CHD/mortality.

Cite This Study

Ariyo et al. (2000) studied this question.

synapsesocial.com/papers/6a121a01bb918b6e5b66a899 https://doi.org/10.1161/01.cir.102.15.1773

View Full Paper

Ask AI

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Depressive Symptoms and Risks of Coronary Heart Disease and Mortality in Elderly Americans

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Depressive Symptoms and Risks of Coronary Heart Disease and Mortality in Elderly Americans

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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