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This review aims to evaluate the potential of exosomes as nanocarriers for delivering therapies across the blood-brain barrier in neurodegenerative diseases.

May 7, 2026Current Drug Delivery

Exosomes as Advanced Nanocarriers: Overcoming the Blood-Brain Barrier for Targeted Therapeutic Delivery in Neurodegenerative Diseases

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Authors

FAFarhang AliakbariNational Institute of Genetic Engineering and Biotechnology MRMehregan RahmaniNational Institute of Genetic Engineering and Biotechnology KMKimia MarzookianNational Institute of Genetic Engineering and Biotechnology

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Review examines exosome mechanisms for overcoming blood-brain barrier, suggesting new neurodegenerative therapies.

Key Points

This review aims to evaluate the potential of exosomes as nanocarriers for delivering therapies across the blood-brain barrier in neurodegenerative diseases.
Analyzed recent studies on exosomes and engineered derivatives for drug delivery in the central nervous system.
Focused on mechanisms of blood-brain barrier penetration and therapeutic cargo delivery in brain disorders.
Synthesized key advances and preclinical studies in engineered exosome applications.
Exosomes utilize receptor-mediated transcytosis and macropinocytosis to cross the blood-brain barrier efficiently.
Their intrinsic cargo can serve as biomarkers and reflect disease states, enhancing targeted delivery.
Engineered exosomes show improved brain specificity and efficacy in preclinical models compared to synthetic carriers.

Cite This Study

Aliakbari et al. (2026) studied this question.

synapsesocial.com/papers/69fc2c4b8b49bacb8b347df2 https://doi.org/10.2174/0115672018430706251211094801

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Exosomes as Advanced Nanocarriers: Overcoming the Blood-Brain Barrier for Targeted Therapeutic Delivery in Neurodegenerative Diseases

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Implication

Key Points

Cite This Study

Exosomes as Advanced Nanocarriers: Overcoming the Blood-Brain Barrier for Targeted Therapeutic Delivery in Neurodegenerative Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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